BIOMATERIALS FOR NANOTECHNOLOGY AND NANOMEDICINE
Morphology of filamentous phage as a bacteria-specific virus
Selection of cancer-targeting peptides by using phage display
Internalization of phage carrying a drug in cancer cells
Our current research is focused on two aspects: (1) the application of biology in nanotechnology and chemistry, and (2) the application of nanotechnology and chemistry in biology and medicine. Specifically, my research group (1) takes advantage of genetic engineering, mineralization and self-assembly of biological macromolecules to build inorganic or bio-inorganic hybrid nanostructures with defined macromolecular architectures and chemical/biological functionalities; (2) mimics biological world to develop novel strategies for the controlled synthesis and assembly of bio-/nano-materials that can be used in energy, photonics and medicine; (3) identifies biomolecular probes that can specifically recognize materials, mammalian cells, and tumor tissues for targeted drug/gene delivery and cancer therapy; AND (4) integrates biological recognition of biomolecular probes and physical/chemical/biological properties of nanomaterials to develop new strategies for bio-imaging and analysis, bone regeneration, targeted drug/gene delivery, and targeted cancer treatment. The following techniques are routinely used in our research: bacterial and mammalian cell culture, molecular cloning, protein expression and purification, phage display, cell surface display, scanning electron microscopy, transmission electron microscopy, atomic force microscopy, bio-nanomaterials synthesis, and bioconjugation.
nanotechnology; nanomedicine; biomaterials